We will find a cure for breast cancer through global research and collaboration

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people diagnosed with breast cancer in 2020 around the world
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of all cancers diagnosed in women is breast cancer
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of all breast cancers are diagnosed in men

Leaders in the field of breast cancer research

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Breast cancer specialists
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patients have participated in BIG trials
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academic research groups dedicated to breast cancer research
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patient-centred clinical trials and programmes are run at any one time

For over 20 years, BIG has been conducting global breast cancer trials and research programmes.

Many are considered to be landmark, introducing particularly innovative designs, contributing to significant breakthroughs, or paving the way towards more personalised treatment of breast cancer.


The international randomised SOFT & TEXT clinical trials offer a new post-operative treatment option for young women with hormone-sensitive early breast cancer.


The APHINITY trial found that adjuvant pertuzumab in combination with trastuzumab and chemotherapy in patients significantly improved the rates of invasive-disease-free survival among patients with HER2-positive, operable breast cancer when it was added to trastuzumab and chemotherapy.


The MINDACT trial found that 46% of patients identified as high-risk for cancer recurrence based on traditional factors were identified as low-risk when adding the MammaPrint® test. It represents a large academic effort towards de-escalating therapies.

Mathilde, Queen of the Belgians is the Honorary President of the Breast International Group

A message from BIG's Honorary President

Finding a cure is one of the biggest challenges faced by researchers from around the world. Breast cancer affects women and men of all ages. This is why prevention is crucial. When breast cancer is diagnosed, the impact on a patient’s life and loved ones is devastating and causes intense stress. Appropriate psychological and moral support is needed and can really make a big difference.

It is crucial to identify the most appropriate and personalised therapies to increase the chances of recovery and cure. BIG fosters collaboration among the world’s leading experts in breast cancer and advances research. This is essential to give hope to everyone concerned. 

HRM the Queen of the Belgians, Honorary President of the Breast International Group

A message from BIG against breast cancer's President

There are many areas of research that hold great promise for patients but have no particular interest for commercial partners.

That is why BIG develops and runs academic studies that hold tremendous potential for patients and promise long-term gains for society, in all regions of the world. Thanks to our global network of breast cancer experts, we can run these trials more efficiently.

– Martine Piccart, Co-founder and President of BIG against breast cancer

Martine Piccart President BIG against breast cancer

Together we are BIG against breast cancer

You too can have an impact on patients' lives


94,4% of all funds received by BIG in 2020, including funds raised by BIG against breast cancer, went directly to BIG's research.

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